![]() ![]() The worst prognosis in CRC patients is associated with molecular mechanisms related to the propagation of cancer stem cells (CSCs). In countries with high human development indices, such as the USA, Japan, Austria, and France, both the mortality rate and incidence of CRC are progressively decreasing in response to improvements in diagnostic procedures, whereas in countries with low development indices, such as the Philippines, China, Brazil, and others, the mortality rate and incidence of CRC are increasing in response to the Westernization of these areas. However, in recent years, this trend is reversing. More than two-thirds of all cases and about 60% of all deaths from CRC occur in countries with a high or very high human development index. ![]() CRC is the third most frequent cancer worldwide, with 1.85 million new cases a year, and the second most deadly, with 881,000 deaths estimated in 2018. ![]() ![]() More than 90% of colorectal carcinomas are adenocarcinomas, originating from the epithelial cells of the colorectal mucosa. Our results provide a step forward in understanding the role of mir-486-5p in CRC and CSC, and suggest that further studies are needed to investigate its diagnostic and prognostic power, possibly in combination with other biomarkers.Ĭolorectal cancer (CRC) is a malignancy of the gastrointestinal tract. In vitro, miR-486-5p was down-regulated in CSC models and it induced an inhibitory effect on stem factors and oncogenes in the main pathways of CSCs. miR-486-5p was also down-regulated in the sera of metastatic patients. In the human study, miR-486-5p was up-regulated in serum and stool of CRC patients in comparison with healthy controls but down-regulated in tumor tissue when compared with normal mucosa. The expression of miR-486-5p was investigated in three different matrices from CRC patients and controls and in CSCs obtained from the CRC cell lines HCT-116, HT-29, and T-84. We investigated the role of hsa-miR-486-5p (miR-486-5p) in CRC, CSCs, and metastasis, in order to reach a better understanding of the biomolecular and epigenetic mechanisms mir-486-5p-related. The deregulation of microRNAs (miRNAs) plays a role in the formation of CSC. Increasing evidences supports the idea that the poor prognosis of patients is related to the presence of cancer stem cells (CSCs), a cell population able to drive cancer recurrence and metastasis. Colorectal cancer (CRC) is the third most frequent cancer worldwide and the second cause of cancer deaths. ![]()
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